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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Genipin, Oxaliplatin
Phytochemical Name Genipin (PubChem CID: 442424 )
Anticancer drug Name Oxaliplatin (PubChem CID: 9887053 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Oxaliplatin
Adverse Reactions Nausea, vomiting, diarrhoea, loss of appetite. This was inferred cold nature anticancer drug.
Recommendations Hot: Datura metel; Citrus reticulata
Reference Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019.　　ref_link
Combination Pair ID: 197
Ref_1
Pair Name Genipin, Oxaliplatin
Disease Info [ICD-11: 2B91] Colorectal cancer Investigative
Biological Phenomena Induction-->Endoplasmic reticulum stress
Gene Regulation Up-regulation Expression BCL2L11 KEGG ID N.A.
Up-regulation Expression BIM hsa10018
Up-regulation Expression ESR1 hsa2099
Up-regulation Expression ROS1 hsa6098
Down-regulation Activity SOD3 hsa6649
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
DLD-1 Colon adenocarcinoma Homo sapiens (Human) CVCL_0248
Result These findings suggest that genipin may be a novel agent for increasing the sensitivity of oxaliplatin against colorectal cancer. The combination of oxaliplatin and genipin hold significant therapeutic potential with minimal adverse effects.
Enhancing Drug Efficacy
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Combination Pair ID: 196
Ref_2
Pair Name Genipin, Oxaliplatin
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Autophagy
Gene Regulation Up-regulation Expression DRAM1 hsa55332
Up-regulation Expression MAP1LC3A hsa84557
Up-regulation Expression TP53 hsa7157
In Vitro Model AGS Gastric adenocarcinoma Homo sapiens (Human) CVCL_0139
MKN45 Gastric adenocarcinoma Homo sapiens (Human) CVCL_0434
MKN28 Gastric tubular adenocarcinoma Homo sapiens (Human) CVCL_1416
Result We showed that genipin increases the oxaliplatin-induced cell death via p53-DRAM autophagy, we suggest that genipin is a sensitizer of oxaliplatin.
03. Reference
No. Title Href
1 Genipin Enhances the Therapeutic Effects of Oxaliplatin by Upregulating BIM in Colorectal Cancer. Mol Cancer Ther. 2019 Apr;18(4):751-761. doi: 10.1158/1535-7163.MCT-18-0196. Click
2 Genipin increases oxaliplatin-induced cell death through autophagy in gastric cancer. J Cancer. 2020 Jan 1;11(2):460-467. doi: 10.7150/jca.34773. Click
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